IgG subclasses in smokers with chronic bronchitis and recurrent exacerbations

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IgG subclasses in smokers with chronic bronchitis and recurrent exacerbations.

BACKGROUND Tobacco smokers have lower serum levels of IgG than non-smokers. IgG subclass deficiency is common in patients with recurrent respiratory infections. Recurrent bronchial infections are common in smokers with chronic bronchitis (CB). We have investigated whether susceptibility to recurrent exacerbations in smokers with CB is associated with altered IgG subclass levels or IgG subclass ...

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Lower airway bacterial colonization in asymptomatic smokers and smokers with chronic bronchitis and recurrent exacerbations.

Bacterial colonization of the lower airways in patients with chronic bronchitis (CB) has been described mainly in patients with co-existing chronic obstructive pulmonary disease (COPD). Although smoking has been identified as a risk factor for bacterial colonization it is not known whether asymptomatic smokers (AS) can be colonized. The aim of this study was to study lower airway bacterial colo...

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Acute exacerbations of chronic bronchitis.

Acute exacerbations of chronic bronchitis are one of the major public health challenges. New data suggest that they will remain so for many years. Although the role of bacteria in the initiation and maintenance of bronchial inflammation, both during and between exacerbations, is well recognized, studies of the long-term effects of therapy are few and inadequate, and the nature of the relationsh...

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Immunological findings in blood and bronchoalveolar lavage fluid in chronic bronchitis patients with recurrent infectious exacerbations.

Bronchial infections are common in smokers and seem to be related to the presence of chronic bronchitis (CB). Why only some smokers develop repeated bronchial infections is not known. The aim of this study was to screen for immunological changes associated with disease in patients with CB and recurrent infectious exacerbations compared to asymptomatic smokers. Sixteen smokers with stable CB and...

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Impact of Acute Exacerbations of Chronic Bronchitis

the broader category of chronic obstructive pulmonary disease (COPD), which is characterized by a chronic, predominantly irreversible reduction in maximal airflow velocity. Chronic bronchitis, emphysema, asthma, and to a lesser extent bronchiectasis comprise the majority of COPD (Figure 1). Chronic bronchitis is a disease process identified clinically as the presence of a productive cough on mo...

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ژورنال

عنوان ژورنال: Thorax

سال: 2001

ISSN: 0040-6376

DOI: 10.1136/thorax.56.6.445